Cisplatin Induced SIADH in Patients Receiving Concurrent Chemoradiation Therapy: A Rare Clinical Observation
Published: November 1, 2018 | DOI: https://doi.org/10.7860/JCDR/2018/37939.12220
Chevireddy Praneetha, Bala Venkat Subramanian, Govindu Vaishnavi Deepthi,
Pettikota Masthan Basha, Pranabandhu Das
1. Junior Resident, Department of Radiation Oncology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhrapradesh, India.
2. Associate Professor, Department of Radiation Oncology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhrapradesh, India.
3. Junior Resident, Department of Radiation Oncology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhrapradesh, India.
4. Junior Resident, Department of Radiation Oncology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhrapradesh, India.
5. Assistant Professor, Department of Radiation Oncology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhrapradesh, India.
Correspondence
Dr. Pranabandhu Das,
Department of Radiation Oncology, SVIMS University Cancer Center, Tirupati-517507, Andhrapradesh, India.
E-mail: daspranabandhu@gmail.com
The Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) can be attributed to various causes such as CNS disorders like head trauma, stroke, pulmonary lesions like TB, bacterial pneumonia, as paraneoplastic syndromes in malignancies, drugs like antidepressants, antineoplastics like cyclophosphamide, vincristine, vinblastine, bortezomib, carboplatin and others. Cisplatin induced SIADH is very uncommon and hence, scarcely reported in literature. Here, we report two cases of dilutional hyponatremia secondary to SIADH that developed in two patients receiving radiotherapy with concomitant cisplatin.
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